EFFECTS OF CHRONIC ALCOHOL ABUSE AND PHYSICAL INACTIVITY ON THE PARAMETERS OF THE DOPAMINERGIC SYSTEM OF SOME PARTS OF THE RAT BRAIN

Purpose of work. To determine the nature changes in content dopamine and its metabolites cerebral cortex, hypothalamus cerebellum rats with chronic alcohol intoxication (CAI) against background physical inactivity (PI). Material methods. The experiments were carried out on outbred white male weighing 180-220 g. Modeling PI was by placing individual cages-pencil cases, limiting their mobility, for periods 14 28 days. simulate CAI, animals provided an ethanol solution as only source fluid Determination components dopaminergic system (tyrosine, 3,4-dioxyphenylalanine, dopamine, homovanillic acid (HVA), dihydroxyphenylacetic (DOPAC) norepinephrine) using ion-pair high-performance liquid chromatography. Results. days is accompanied signs activation cortex rats. With CAI a period days, there are decrease activity cortex. combined effect leads to increase turnover Conclusions. PI, most pronounced observed 14th day levels HVA DOPAC, 28th concentration HVA.